Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.
Paediatr Drugs. 2023 Nov;25(6):659-676. doi: 10.1007/s40272-023-00595-6. Epub 2023 Oct 2.
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that manifests as painful, deep-seated, inflamed nodules and abscesses in the axillary, groin, perianal, perineal, and inframammary regions. The associated pain, malodour, and disfigurement contribute to its profound negative impact on psychosocial spheres and overall quality of life in affected individuals. Although the symptoms of HS classically begin in the second or third decade of life, HS affects children and adolescents as well. Despite this, there are limited pediatric data on treatment, which are largely based on expert opinion, extrapolation of efficacy data in adults with HS, and safety information from medication use in other pediatric diseases. On this basis, there exist several pharmacological modalities in the treatment of children and adolescents with HS including topical therapies, systemic therapies, and biologics. The goals of this review article are to: (1) review the efficacy of different pharmacological treatment modalities in children and adolescents with HS, and (2) review the safety and monitoring considerations of the different treatment options in children and adolescents with HS.
化脓性汗腺炎（HS）是一种慢性、复发性、炎症性皮肤病，表现为腋窝、腹股沟、肛周、会阴和乳晕下区域疼痛、深在性、发炎的结节和脓肿。其相关的疼痛、恶臭和畸形导致其对受影响个体的心理社会领域和整体生活质量产生深远的负面影响。尽管 HS 的症状通常在生命的第二或第三个十年开始，但它也会影响儿童和青少年。尽管如此，关于治疗的儿科数据有限，这些数据主要基于专家意见、HS 成人疗效数据的推断以及其他儿科疾病药物使用的安全性信息。在此基础上，HS 儿童和青少年的治疗存在几种药理学方法，包括局部治疗、全身治疗和生物制剂。本文的目的是：（1）综述不同药理学治疗方法在 HS 儿童和青少年中的疗效，（2）综述不同治疗方案在 HS 儿童和青少年中的安全性和监测注意事项。
