Reproductive and Perinatal Epidemiology Research Unit, The University of New South Wales, NSW, Australia.
BJOG. 2010 Dec;117(13):1628-34. doi: 10.1111/j.1471-0528.2010.02731.x. Epub 2010 Sep 28.
To assess the effect on the human sex ratio at birth by assisted reproductive technology (ART) procedures.
Retrospective population-based study.
Fertility clinics in Australia and New Zealand.
The study included 13,368 babies by 13,165 women who had a single embryo transfer (SET) between 2002 and 2006.
Logistic regression was used to model the effect on the sex ratio at birth of ART characteristics [in vitro fertilisation (IVF) or intracytoplasmic sperm insemination (ICSI) SET, cleavage-stage or blastocyst SET, and fresh or thawed SET] and biological characteristics (woman's and partner's age and cause of infertility).
Proportion of male births.
The crude sex ratio at birth was 51.3%. Individual ART procedures had a significant effect on the sex ratio at birth. More males were born following IVF SET (53.0%) than ICSI SET (50.0%), and following blastocyst SET (54.1%) than cleavage-stage SET (49.9%). For a specific ART regimen, IVF blastocyst SET produced more males (56.1%) and ICSI cleavage-stage SET produced fewer males (48.7%).
The change in the sex ratio at birth of SET babies is associated with the ART regimen. The mechanism of these effects remains unclear. Fertility clinics and patients should be aware of the bias in the sex ratio at birth when using ART procedures.
评估辅助生殖技术（ART）程序对出生人口性别比的影响。
回顾性基于人群的研究。
澳大利亚和新西兰的生育诊所。
这项研究包括了 2002 年至 2006 年间进行了单次胚胎移植（SET）的 13165 名妇女所生育的 13368 名婴儿。
使用逻辑回归模型分析了 ART 特征（体外受精（IVF）或胞浆内精子注射（ICSI）SET、卵裂期或囊胚期 SET、新鲜或解冻 SET）和生物学特征（妇女和伴侣的年龄和不孕原因）对出生人口性别比的影响。
男性出生比例。
出生人口性别比的粗比值为 51.3%。单独的 ART 程序对出生人口性别比有显著影响。IVF SET（53.0%）比 ICSI SET（50.0%）、囊胚期 SET（54.1%）比卵裂期 SET（49.9%）更容易生男孩。对于特定的 ART 方案，IVF 囊胚期 SET 产生的男孩更多（56.1%），而 ICSI 卵裂期 SET 产生的男孩更少（48.7%）。
SET 婴儿出生人口性别比的变化与 ART 方案有关。这些影响的机制尚不清楚。使用 ART 程序时，生育诊所和患者应注意出生人口性别比的偏差。
