Department of Obstetrics and Gynecology, Hefei Maternal and Child Health Hospital, Hefei, 230001, China.
Department of Obstetrics and Gynecology, Anhui Women and Children's Medical Center,, Hefei, 230001, China.
BMC Pregnancy Childbirth. 2024 May 2;24(1):337. doi: 10.1186/s12884-024-06521-z.
To evaluate monochorionic diamniotic (MCDA) and dichorionic diamniotic (DCDA) twin pregnancies conceived by assisted reproductive technology (ART) and conceived naturally.
We retrospectively analyzed the data on twin pregnancies conceived by ART from January 2015 to January 2022,and compared pregnancy outcomes of MCDA and DCDA twins conceived by ART with those of MCDA and DCDA twins conceived naturally, pregnancy outcomes between MCDA and DCDA twins conceived by ART, and pregnancy outcomes of DCT and TCT pregnancies reduced to DCDA pregnancies with those of DCDA pregnancies conceived naturally.
MCDA pregnancies conceived by ART accounted for 4.21% of the total pregnancies conceived by ART and 43.81% of the total MCDA pregnancies. DCDA pregnancies conceived by ART accounted for 95.79% of the total pregnancies conceived by ART and 93.26% of the total DCDA pregnancies. Women with MCDA pregnancies conceived by ART had a higher premature delivery rate, lower neonatal weights, a higher placenta previa rate, and a lower twin survival rate than those with MCDA pregnancies conceived naturally (all p < 0.05). Women with DCDA pregnancies conceived naturally had lower rates of preterm birth, higher neonatal weights, and higher twin survival rates than women with DCDA pregnancies conceived by ART and those with DCT and TCT pregnancies reduced to DCDA pregnancies (all p < 0.05).
Our study confirms that the pregnancy outcomes of MCDA pregnancies conceived by ART are worse than those of MCDA pregnancies conceived naturally. Similarly, the pregnancy outcomes of naturally-conceived DCDA pregnancies are better than those of DCDA pregnancies conceived by ART and DCT and TCT pregnancies reduced to DCDA pregnancies.
评估辅助生殖技术（ART）受孕的单绒毛膜双羊膜囊（MCDA）和双绒毛膜双羊膜囊（DCDA）双胎妊娠与自然受孕的双胎妊娠的结局。
我们回顾性分析了 2015 年 1 月至 2022 年 1 月期间接受 ART 的双胎妊娠数据，并比较了 MCDA 和 DCDA 双胎妊娠与自然受孕的 MCDA 和 DCDA 双胎妊娠、ART 受孕的 MCDA 和 DCDA 双胎妊娠、DCT 和 TCT 妊娠减胎为 DCDA 妊娠与自然受孕的 DCDA 妊娠的结局。
ART 受孕的 MCDA 妊娠占 ART 总妊娠的 4.21%，占 MCDA 总妊娠的 43.81%。ART 受孕的 DCDA 妊娠占 ART 总妊娠的 95.79%，占 DCDA 总妊娠的 93.26%。ART 受孕的 MCDA 妊娠孕妇早产率更高、新生儿体重更低、前置胎盘发生率更高、双胎存活率更低，与自然受孕的 MCDA 妊娠孕妇比较，差异均有统计学意义（均 P<0.05）。与自然受孕的 DCDA 妊娠孕妇相比，ART 受孕的 DCDA 妊娠孕妇早产率更低、新生儿体重更高、双胎存活率更高，DCT 和 TCT 妊娠减胎为 DCDA 妊娠孕妇与自然受孕的 DCDA 妊娠孕妇相比，差异均有统计学意义（均 P<0.05）。
本研究证实，ART 受孕的 MCDA 妊娠结局不如自然受孕的 MCDA 妊娠结局好。同样，自然受孕的 DCDA 妊娠结局优于 ART 受孕的 DCDA 妊娠结局以及 DCT 和 TCT 妊娠减胎为 DCDA 妊娠结局。
