Laboratoire de Génomique des Microorganismes, FRE3214 CNRS, Université Pierre et Marie Curie, Paris, France.
FEBS Lett. 2010 Oct 22;584(20):4273-9. doi: 10.1016/j.febslet.2010.09.030. Epub 2010 Sep 26.
This review focuses on the posttranscriptional processes which govern mitochondrial biogenesis, with a special emphasis on the asymmetric localization-translation of nuclear-encoded mRNAs as an important regulatory step of the protein import process. We review how spatio-temporal mRNA regulons help to elicit timely, versatile, and coordinated intracellular processes to assemble mitochondrial structures. Our current knowledge on the mitochondrial import of respiratory chain assembly factors and the role of the ribonucleic acid (RNA) binding protein Puf3 are presented. A connection with the target of rapamycine signalling pathway may explain how respiratory chain assembly senses environmental conditions via the protein import machinery.
这篇综述重点介绍了调控线粒体生物发生的转录后过程，特别强调了核编码 mRNA 的不对称定位-翻译作为蛋白质输入过程的一个重要调控步骤。我们回顾了时空 mRNA 调控物如何帮助引发及时、多样和协调的细胞内过程来组装线粒体结构。我们介绍了当前关于呼吸链组装因子的线粒体输入和 RNA 结合蛋白 Puf3 作用的知识。与雷帕霉素信号通路的靶标之间的联系可能解释了呼吸链组装如何通过蛋白质输入机制感知环境条件。
