Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA.
IEEE Trans Biomed Eng. 2011 Jan;58(1):36-42. doi: 10.1109/TBME.2010.2080678. Epub 2010 Sep 27.
A pupillary light reflex (PLR) model was proposed in this paper by considering the iris muscle mechanical properties and modulation inputs from both parasympathetic and sympathetic systems. The model can describe very well the experimental PLR responses induced by a short light flash of various intensities. In addition, an inverse method was developed to fit numerically this model to experimental PLR data. The model was tested in experimental human PLR data to extract separately the parasympathetic and sympathetic modulations during PLR. The results indicated a higher parasympathetic and a lower sympathetic activity in females than in males, which was consistent with previous findings in cardiovascular studies. This new model may help improve our understanding of the PLR process and could be applied to analyze autonomic nervous interaction during pupillary responses.
本文提出了一种瞳孔光反射（PLR）模型，该模型考虑了虹膜肌肉的力学特性以及来自副交感和交感系统的调制输入。该模型可以很好地描述各种强度的短光闪光诱导的实验 PLR 反应。此外，还开发了一种逆方法来数值拟合该模型到实验 PLR 数据。该模型在实验性人类 PLR 数据中进行了测试，以在 PLR 期间分别提取副交感和交感调节。结果表明，女性的副交感神经活动高于男性，而交感神经活动低于男性，这与心血管研究中的先前发现一致。这种新模型可能有助于我们更好地理解 PLR 过程，并可应用于分析瞳孔反应期间自主神经相互作用。
