Barbur J L, Moro S, Harlow J A, Lam B L, Liu M
The Henry Wellcome Laboratories for Vision Sciences, Applied Vision Research Centre, City University, Northampton Square, London EC1V 0HB, UK.
Clin Neurophysiol. 2004 Nov;115(11):2650-8. doi: 10.1016/j.clinph.2004.05.022.
The pupil response to light flux increments is abnormal in severe optic neuritis, but little is known about the effects of this condition on the pupil colour response. The aim of this study was to examine how optic neuritis affects pupil responses to light flux and colour modulation and the extent to which such pupil responses mirror the loss and recovery of vision.
A new pupil examination technique that makes use of sinusoidal modulation of either luminance contrast or chromatic saturation was employed. This technique enables the automatic extraction of both pupil response amplitude and latency and achieves a high signal to noise ratio with fewer averages.
The study reveals a greater loss of pupil response amplitude and significantly longer latencies to chromatic modulation (i.e. approximately 80 ms). Stimulation of the unaffected eye in the optic neuritis group results in smaller response amplitudes when compared to the normal group for both light flux and colour modulation.
Pupil response components can be affected differently in optic neuritis. These findings suggest that the pupil colour response, in particular, may provide a useful, objective estimator to judge the extent of damage and recovery in diseases of the optic nerve.
在严重视神经炎中，瞳孔对光通量增加的反应是异常的，但对于这种情况对瞳孔颜色反应的影响知之甚少。本研究的目的是研究视神经炎如何影响瞳孔对光通量和颜色调制的反应，以及这种瞳孔反应在多大程度上反映了视力的丧失和恢复。
采用一种新的瞳孔检查技术，该技术利用亮度对比度或色度饱和度的正弦调制。这种技术能够自动提取瞳孔反应幅度和潜伏期，并且用较少的平均值就能实现高信噪比。
研究发现瞳孔反应幅度的损失更大，对颜色调制的潜伏期明显更长（即约80毫秒）。与正常组相比，视神经炎组未受影响的眼睛在光通量和颜色调制方面受到刺激时，反应幅度更小。
在视神经炎中，瞳孔反应成分可能受到不同的影响。这些发现表明，特别是瞳孔颜色反应，可能为判断视神经疾病的损伤程度和恢复情况提供一个有用的客观指标。
