Department of Pediatrics, University of Oulu, Oulu, Finland.
Diabetes Care. 2011 Jan;34(1):115-7. doi: 10.2337/dc10-1091. Epub 2010 Sep 27.
To determine the extended family history of diabetes or autoimmune diseases in families with and without children having type 1 diabetes.
Three hundred case families and 381 control families were interviewed using structured questionnaires.
The proportion of case children having at least one relative with type 1 diabetes outside the nuclear family was higher than that of control children (50.3 vs. 31.8%, P < 0.001). The proportions of case and control children having relatives with type 2 diabetes or gestational diabetes were similar. Other autoimmune diseases occurred more frequently among the case children (9.7 vs. 1.1%, P < 0.001), in the case nuclear families (22.0 vs. 12.9%, P = 0.002) and in relatives outside the case nuclear family (72.0 vs. 62.2%, P = 0.007).
Type 1 diabetes and autoimmune diseases not only cluster in the nuclear families of children with type 1 diabetes but are also overrepresented in their extended families.
确定有和无 1 型糖尿病患儿的家族中糖尿病或自身免疫性疾病的家族史。
采用结构化问卷对 300 个病例家庭和 381 个对照家庭进行了访谈。
与对照组相比，有核家庭以外至少有一位亲属患有 1 型糖尿病的患儿比例更高（50.3% vs. 31.8%，P < 0.001）。患儿亲属中患有 2 型糖尿病或妊娠期糖尿病的比例相似。病例组患儿发生其他自身免疫性疾病的频率更高（9.7% vs. 1.1%，P < 0.001），在病例核心家庭中更常见（22.0% vs. 12.9%，P = 0.002），在病例核心家庭以外的亲属中也更常见（72.0% vs. 62.2%，P = 0.007）。
1 型糖尿病和自身免疫性疾病不仅在 1 型糖尿病患儿的核心家庭中聚集，而且在其大家庭中也更为常见。
