中老龄人群研究中的生物标志物：方案、方法、样本和比较背景。
Bioindicators in the MIDUS national study: protocol, measures, sample, and comparative context.
机构信息
Institute on Aging, 2245 Medical Sciences Center, University of Wisconsin, Madison 53706, USA.
出版信息
J Aging Health. 2010 Dec;22(8):1059-80. doi: 10.1177/0898264310374355. Epub 2010 Sep 27.
OBJECTIVES
Midlife in the United States (MIDUS) is a national study of health and aging among individuals aged 25 to 74 at baseline (1995-1996). Longitudinal survey assessments (2004-2005), were followed by biological assessments on a subsample (aged 35-85).To facilitate public use, we describe the protocol, measures, and sample.
METHOD
Respondents traveled to clinics for a 2-day data-collection protocol that included fasting blood specimens, 12-hr urine specimen, medical history, physical exam, bone densitometry, and a laboratory challenge (heart rate variability, blood pressure, respiration, salivary cortisol).
RESULTS
Response rates for the biological protocol (N = 1,255) were 39.3% or 43.1% (adjusting for those who could not be located or contacted). Reasons for nonparticipation were travel, family obligations, and being too busy. Respondents were comparable to the recruitment pool on most demographic characteristics and health assessments.
DISCUSSION
Strengths of the protocol vis-à-vis similar studies include opportunities to link biological factors with diverse content from other MIDUS projects.
目的
美国中年研究（MIDUS）是一项针对 25 至 74 岁个体的健康和衰老的全国性研究。纵向调查评估（2004-2005 年）之后，对亚组（年龄 35-85 岁）进行了生物评估。为了便于公众使用，我们描述了方案、措施和样本。
方法
受访者前往诊所进行为期两天的数据收集方案，包括空腹血样、12 小时尿液样本、病史、体检、骨密度测定和实验室挑战（心率变异性、血压、呼吸、唾液皮质醇）。
结果
生物方案的响应率（N=1255）为 39.3%或 43.1%（根据无法找到或联系的人进行调整）。不参与的原因是旅行、家庭义务和太忙。与招募群体相比，受访者在大多数人口统计学特征和健康评估方面具有可比性。
讨论
与类似研究相比，该方案的优势在于有机会将生物因素与来自其他 MIDUS 项目的多样化内容联系起来。
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