Department of Pathology and Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Armour Academic Center, 600 S Paulina St, Suite 1022F, Chicago, IL 60612, USA.
Stroke. 2010 Oct;41(10 Suppl):S144-6. doi: 10.1161/STROKEAHA.110.598326.
Vascular and neurodegenerative disease commonly cooccur in older persons. We review findings from the Rush Religious Orders Study and Memory and Aging Project. Both studies enroll subjects without diagnosed dementia, perform annual evaluations, and obtain autopsies proximate to death. We found that macroscopic infarcts are common, lower the threshold for cognitive impairment, and often coexist with Alzheimer's disease pathology. We also found that vascular pathology may be associated with memory impairment and may be difficult to distinguish from clinical Alzheimer's disease. Finally, because dementia in older persons often results from mixed pathology and the clinical phenotypes overlap, some risk factors may increase risk for clinical Alzheimer's disease through an increase in vascular pathology.
血管性和神经退行性疾病在老年人中常同时发生。我们回顾了拉什宗教秩序研究和记忆与衰老项目的研究结果。这两项研究均招募了没有诊断为痴呆的受试者，每年进行评估，并在接近死亡时进行尸检。我们发现，大的梗死灶很常见，认知障碍的阈值降低，并且常与阿尔茨海默病病理共存。我们还发现，血管病变可能与记忆障碍有关，并且可能难以与临床阿尔茨海默病相区分。最后，由于老年人的痴呆症通常是由混合性病变引起的，且临床表型重叠，一些危险因素可能会通过增加血管病变而增加患临床阿尔茨海默病的风险。
