Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA. David A
J Alzheimers Dis. 2013;33 Suppl 1(0):S397-403. doi: 10.3233/JAD-2012-129007.
The Religious Orders Study and the Rush Memory and Aging Project are both cohort studies of aging and dementia that include organ donation at death. Together, more than 2,700 persons have agreed to annual clinical evaluation and brain donation at death. A subset of participants also participated in a substudy that included ante-mortem imaging. We highlight recent findings that have been highly cited over the past five years. The findings fall into three general categories. The first relates to the neuropathology of probable Alzheimer's disease, mild cognitive impairment, and those without dementia or mild cognitive impairment. The second relates to risk factors for Alzheimer's disease and neuropathology. The third are clinical and imaging studies of mild cognitive impairment. The findings illustrate the range of insights that can be gained into cognitive aging by incorporating neuropathologic indices into well designed, prospective cohort studies.
宗教秩序研究和拉什记忆与衰老项目都是针对衰老和痴呆的队列研究，包括死后器官捐献。共有 2700 多人同意每年进行临床评估并在死后捐献大脑。部分参与者还参加了包括生前成像的子研究。我们重点介绍了过去五年中被高度引用的最新发现。这些发现分为三类。第一类与可能的阿尔茨海默病、轻度认知障碍以及没有痴呆或轻度认知障碍的患者的神经病理学有关。第二类与阿尔茨海默病和神经病理学的风险因素有关。第三类是轻度认知障碍的临床和影像学研究。这些发现说明了通过将神经病理学指标纳入精心设计的前瞻性队列研究，可以深入了解认知衰老的范围。
