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原位 MWCNT 在生物组织中近红外激光辐照下的时空热动力学

Spatio-temporal thermal kinetics of in situ MWCNT heating in biological tissues under NIR laser irradiation.

机构信息

Department of Biological and Agricultural Engineering, Louisiana State University Agricultural Center, Baton Rouge, LA 70803-4505, USA.

出版信息

Nanotechnology. 2010 Oct 29;21(43):435101. doi: 10.1088/0957-4484/21/43/435101. Epub 2010 Sep 29.

Abstract

Carbon nanotubes have many potential applications in life sciences and engineering as they have very high absorbance in the near-infrared (NIR) spectrum, while biological tissues do not. The purpose of this study was to determine the effect of 1064 nm NIR laser power levels on the spatial temperature distribution and the temperature kinetics in mammalian tissue at both macroscopic and microscopic scales. The model tissue was the 'flat' of a chicken wing (the section containing the radius and ulna), which was injected under the skin in the subcutaneous layer of tissue. Specimens were exposed to laser radiation and an infrared thermography system was used to measure and record the temperature distributions in the specimens at both the macroscopic and microscopic scales. Experimental results concluded that power levels of 1536 mW easily achieved hyperthermic temperatures with localized values as high as 172.7 °C.

摘要

碳纳米管在生命科学和工程中有许多潜在的应用,因为它们在近红外(NIR)光谱中有非常高的吸收率,而生物组织则没有。本研究的目的是确定 1064nmNIR 激光功率水平对宏观和微观尺度上哺乳动物组织中空间温度分布和温度动力学的影响。模型组织是鸡翅膀的“平面”(包含桡骨和尺骨的部分),它被注射到皮下组织的皮下层。将标本暴露在激光辐射下,并使用红外热成像系统测量和记录标本在宏观和微观尺度上的温度分布。实验结果表明,1536mW 的功率水平很容易达到高温,局部温度高达 172.7°C。

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