碳纳米管在热疗中的应用。
Carbon nanotubes in hyperthermia therapy.
机构信息
Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.
出版信息
Adv Drug Deliv Rev. 2013 Dec;65(15):2045-60. doi: 10.1016/j.addr.2013.08.001. Epub 2013 Aug 8.
Abstract
Thermal tumor ablation therapies are being developed with a variety of nanomaterials, including single- and multiwalled carbon nanotubes. Carbon nanotubes (CNTs) have attracted interest due to their potential for simultaneous imaging and therapy. In this review, we highlight in vivo applications of carbon nanotube-mediated thermal therapy (CNMTT) and examine the rationale for use of this treatment in recurrent tumors or those resistant to conventional cancer therapies. Additionally, we discuss strategies to localize and enhance the cancer selectivity of this treatment and briefly examine issues relating the toxicity and long term fate of CNTs.
摘要
热肿瘤消融疗法正在使用各种纳米材料进行开发，包括单壁和多壁碳纳米管。由于其同时进行成像和治疗的潜力，碳纳米管 (CNT) 引起了人们的兴趣。在这篇综述中，我们重点介绍了碳纳米管介导的热疗 (CNMTT) 的体内应用，并研究了将这种治疗方法用于复发性肿瘤或对传统癌症治疗方法有抗性的肿瘤的原理。此外，我们还讨论了使这种治疗方法定位和增强癌症选择性的策略，并简要探讨了与 CNT 毒性和长期归宿相关的问题。
相似文献
1
Carbon nanotubes in hyperthermia therapy.碳纳米管在热疗中的应用。
Adv Drug Deliv Rev. 2013 Dec;65(15):2045-60. doi: 10.1016/j.addr.2013.08.001. Epub 2013 Aug 8.
2
Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes.使用多壁碳纳米管对黑色素瘤肿瘤进行光热治疗。
Int J Nanomedicine. 2017 Jun 20;12:4509-4517. doi: 10.2147/IJN.S134661. eCollection 2017.
3
Cancer Therapy and Imaging Through Functionalized Carbon Nanotubes Decorated with Magnetite and Gold Nanoparticles as a Multimodal Tool.基于功能化碳纳米管的磁性金纳米粒子的癌症治疗与成像：多功能诊疗一体化工具
Appl Biochem Biotechnol. 2020 Jul;191(3):1280-1293. doi: 10.1007/s12010-020-03280-3. Epub 2020 Feb 22.
4
Thermal ablation therapeutics based on CN(x) multi-walled nanotubes.基于碳氮（CN(x)）多壁纳米管的热消融疗法。
Int J Nanomedicine. 2007;2(4):707-14.
5
Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.利用单壁碳纳米管-肽复合物进行肿瘤细胞光热消融。
J Control Release. 2014 Jan 10;173:59-66. doi: 10.1016/j.jconrel.2013.10.039. Epub 2013 Nov 6.
6
Advances in cancer therapy through the use of carbon nanotube-mediated targeted hyperthermia.通过使用碳纳米管介导的靶向热疗来推进癌症治疗。
Int J Nanomedicine. 2011;6:1675-84. doi: 10.2147/IJN.S23588. Epub 2011 Aug 15.
7
Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation.单次使用多壁碳纳米管和近红外辐射治疗肾肿瘤后的长期存活情况。
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12897-902. doi: 10.1073/pnas.0905195106. Epub 2009 Jul 20.
8
Carbon nanotubes in cancer diagnosis and therapy.碳纳米管在癌症诊断与治疗中的应用
Biochim Biophys Acta. 2010 Aug;1806(1):29-35. doi: 10.1016/j.bbcan.2010.02.004. Epub 2010 Feb 26.
9
Recent advances on hyperthermia therapy applications of carbon-based nanocomposites.基于碳纳米复合材料的热疗应用的最新进展。
Colloids Surf B Biointerfaces. 2023 Aug;228:113430. doi: 10.1016/j.colsurfb.2023.113430. Epub 2023 Jun 29.
10
Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy.载铁多壁碳纳米管的制备及其在磁共振引导激光热疗中的应用。
Nanomedicine (Lond). 2011 Oct;6(8):1341-52. doi: 10.2217/nnm.11.37. Epub 2011 Apr 20.
引用本文的文献
1
Biomedical Applications of Carbon-Based Nanomaterials: Exploring Recent Advances in Therapeutics, Diagnostics, and Tissue Engineering.碳基纳米材料的生物医学应用：探索治疗、诊断和组织工程领域的最新进展
Adv Pharm Bull. 2025 May 31;15(2):232-247. doi: 10.34172/apb.025.44083. eCollection 2025 Jul.
2
The role of nanomedicine and artificial intelligence in cancer health care: individual applications and emerging integrations-a narrative review.纳米医学与人工智能在癌症医疗中的作用：个体应用与新兴整合——一项叙述性综述
Discov Oncol. 2025 May 8;16(1):697. doi: 10.1007/s12672-025-02469-4.
3
Hydrothermal carbonization synthesis of amorphous carbon nanoparticles (15-150 nm) with fine-tuning of the size, bulk order, and the consequent impact on antioxidant and photothermal properties.水热碳化合成非晶态碳纳米颗粒（15 - 150纳米），可对其尺寸、整体有序性进行微调，并由此影响其抗氧化和光热性能。
Nanoscale Adv. 2025 Jan 8;7(5):1391-1404. doi: 10.1039/d4na00923a. eCollection 2025 Feb 25.
4
Therapeutic applications of carbon nanomaterials in renal cancer.碳纳米材料在肾癌治疗中的应用。
Biotechnol Lett. 2023 Dec;45(11-12):1395-1416. doi: 10.1007/s10529-023-03429-0. Epub 2023 Oct 21.
5
Advanced Theranostic Strategies for Viral Hepatitis Using Carbon Nanostructures.使用碳纳米结构的病毒性肝炎先进诊疗策略
Micromachines (Basel). 2023 Jun 1;14(6):1185. doi: 10.3390/mi14061185.
6
Folic acid-maltodextrin polymer coated magnetic graphene oxide as a NIR-responsive nano-drug delivery system for chemo-photothermal synergistic inhibition of tumor cells.叶酸-麦芽糖糊精聚合物包覆的磁性氧化石墨烯作为一种近红外响应性纳米药物递送系统用于肿瘤细胞的化学-光热协同抑制
RSC Adv. 2023 Apr 24;13(18):12609-12617. doi: 10.1039/d3ra02306k. eCollection 2023 Apr 17.
7
Carbon-Based Nanomaterials as Drug Delivery Agents for Colorectal Cancer: Clinical Preface to Colorectal Cancer Citing Their Markers and Existing Theranostic Approaches.基于碳的纳米材料作为结直肠癌的药物递送剂：结直肠癌的临床前言，引用其标志物和现有的治疗诊断方法
ACS Omega. 2023 Mar 14;8(12):10656-10668. doi: 10.1021/acsomega.2c06242. eCollection 2023 Mar 28.
8
MXene-Carbon Nanotube Composites: Properties and Applications.MXene-碳纳米管复合材料：性质与应用
Nanomaterials (Basel). 2023 Jan 14;13(2):345. doi: 10.3390/nano13020345.
9
Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential.用于癌症治疗的基于纳米颗粒的光疗系统：现状与临床潜力
Bioact Mater. 2022 Dec 5;23:471-507. doi: 10.1016/j.bioactmat.2022.11.013. eCollection 2023 May.
10
Easy, Fast Self-Heating Polyurethane Nanocomposite with the Introduction of Thermally Annealed Carbon Nanotubes Using Near-Infrared Lased Irradiation.通过近红外激光辐照引入热退火碳纳米管制备的简便、快速自热聚氨酯纳米复合材料。
Materials (Basel). 2022 Nov 28;15(23):8463. doi: 10.3390/ma15238463.
本文引用的文献
1
NIR-/pH-Responsive drug delivery of functionalized single-walled carbon nanotubes for potential application in cancer chemo-photothermal therapy.功能化单壁碳纳米管的近红外-/pH 响应药物递送用于癌症化学-光热治疗的潜在应用。
Pharm Res. 2013 Nov;30(11):2757-71. doi: 10.1007/s11095-013-1095-3. Epub 2013 Jun 14.
2
Asbestos-like pathogenicity of long carbon nanotubes alleviated by chemical functionalization.化学功能化减轻长碳纳米管的石棉样致病性。
Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2274-8. doi: 10.1002/anie.201207664. Epub 2013 Jan 14.
3
Safety considerations for graphene: lessons learnt from carbon nanotubes.石墨烯的安全性考虑：从碳纳米管中吸取的教训。
Acc Chem Res. 2013 Mar 19;46(3):692-701. doi: 10.1021/ar300199e. Epub 2012 Nov 20.
4
Multifunctional in vivo vascular imaging using near-infrared II fluorescence.近红外二区荧光多功能体内血管成像
Nat Med. 2012 Dec;18(12):1841-6. doi: 10.1038/nm.2995. Epub 2012 Nov 18.
5
Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes.半导体和富金属单壁碳纳米管的光动力和光热效应。
J Am Chem Soc. 2012 Oct 31;134(43):17862-5. doi: 10.1021/ja3079972. Epub 2012 Oct 19.
6
Heat localization for targeted tumor treatment with nanoscale near-infrared radiation absorbers.利用纳米级近红外辐射吸收剂进行靶向肿瘤热疗定位。
Phys Med Biol. 2012 Sep 21;57(18):5765-75. doi: 10.1088/0031-9155/57/18/5765. Epub 2012 Sep 5.
7
A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue.致密的聚乙二醇涂层可提高大聚合物纳米颗粒在脑组织内的穿透性。
Sci Transl Med. 2012 Aug 29;4(149):149ra119. doi: 10.1126/scitranslmed.3003594.
8
Effects of long and short carboxylated or aminated multiwalled carbon nanotubes on blood coagulation.长、短羧基化或氨基化多壁碳纳米管对凝血功能的影响。
PLoS One. 2012;7(7):e38995. doi: 10.1371/journal.pone.0038995. Epub 2012 Jul 10.
9
In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex.脑皮层立体定向给药后功能化碳纳米管的体内降解。
Nanomedicine (Lond). 2012 Oct;7(10):1485-94. doi: 10.2217/nnm.12.33. Epub 2012 Jun 19.
10
Glioblastoma: therapeutic challenges, what lies ahead.胶质母细胞瘤：治疗挑战，未来何去何从。
Biochim Biophys Acta. 2012 Dec;1826(2):338-49. doi: 10.1016/j.bbcan.2012.05.004. Epub 2012 Jun 5.
Zotero 插件