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碳纳米管在热疗中的应用。

Carbon nanotubes in hyperthermia therapy.

机构信息

Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA.

出版信息

Adv Drug Deliv Rev. 2013 Dec;65(15):2045-60. doi: 10.1016/j.addr.2013.08.001. Epub 2013 Aug 8.

DOI:10.1016/j.addr.2013.08.001
PMID:23933617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3914717/
Abstract

Thermal tumor ablation therapies are being developed with a variety of nanomaterials, including single- and multiwalled carbon nanotubes. Carbon nanotubes (CNTs) have attracted interest due to their potential for simultaneous imaging and therapy. In this review, we highlight in vivo applications of carbon nanotube-mediated thermal therapy (CNMTT) and examine the rationale for use of this treatment in recurrent tumors or those resistant to conventional cancer therapies. Additionally, we discuss strategies to localize and enhance the cancer selectivity of this treatment and briefly examine issues relating the toxicity and long term fate of CNTs.

摘要

热肿瘤消融疗法正在使用各种纳米材料进行开发，包括单壁和多壁碳纳米管。由于其同时进行成像和治疗的潜力，碳纳米管 (CNT) 引起了人们的兴趣。在这篇综述中，我们重点介绍了碳纳米管介导的热疗 (CNMTT) 的体内应用，并研究了将这种治疗方法用于复发性肿瘤或对传统癌症治疗方法有抗性的肿瘤的原理。此外，我们还讨论了使这种治疗方法定位和增强癌症选择性的策略，并简要探讨了与 CNT 毒性和长期归宿相关的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/c2c1db4bafb6/nihms519235f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/093d1eac15f7/nihms519235f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/ca9e1e2284a1/nihms519235f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/cbb77b478188/nihms519235f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/a8bf845114dc/nihms519235f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/c2c1db4bafb6/nihms519235f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/093d1eac15f7/nihms519235f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/ca9e1e2284a1/nihms519235f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/cbb77b478188/nihms519235f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/a8bf845114dc/nihms519235f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b4/3914717/c2c1db4bafb6/nihms519235f5.jpg

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Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2274-8. doi: 10.1002/anie.201207664. Epub 2013 Jan 14.
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Safety considerations for graphene: lessons learnt from carbon nanotubes.
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Nanoscale Adv. 2025 Jan 8;7(5):1391-1404. doi: 10.1039/d4na00923a. eCollection 2025 Feb 25.
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