鸦片对糖尿病大鼠、成瘾大鼠及成瘾糖尿病大鼠血清转化生长因子-β水平的影响。
Impact of opium on the serum levels of TGF-β in diabetic, addicted and addicted-diabetic rats.
作者信息
Asadikaram Gholamreza, Asiabanha Majid, Sayadi Ahmadreza, Jafarzadeh Abdollah, Hassanshahi Gholamhossein
机构信息
Department of Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, e-mail:
出版信息
Iran J Immunol. 2010 Sep;7(3):186-92.
BACKGROUND
Several cells of immune system such as regulatory T cells and macrophages secrete transforming growth factor-β (TGF-β) in response to different stimuli. This cytokine has inhibitory effect on immune system and diminished production of this cytokine is associated with autoimmune disorders.
OBJECTIVE
The aim of this study was to evaluate the influence of opium addiction on serum level of TGF-β in male and female diabetic and non-diabetic Wistar rats.
METHODS
This experimental study was performed on normal, opium addicted, diabetic and addicted-diabetic male and female rats. Serum level of TGF-β was measured by ELISA.
RESULTS
The results of our study indicated that the mean serum level of TGF-β in female addicted rats was significantly increased compared to control group (p<0.004). Conversely, in male addicted rats the mean serum level of TGF-β was lower compared with control (p<0.065).
CONCLUSION
Our results suggest that opium and its derivatives have differential inductive effects on the cytokine expression in male and female rats.
背景
免疫系统的几种细胞，如调节性T细胞和巨噬细胞，会在不同刺激下分泌转化生长因子-β（TGF-β）。这种细胞因子对免疫系统具有抑制作用，其产生减少与自身免疫性疾病有关。
目的
本研究旨在评估鸦片成瘾对雄性和雌性糖尿病及非糖尿病Wistar大鼠血清TGF-β水平的影响。
方法
本实验研究对正常、鸦片成瘾、糖尿病及成瘾糖尿病的雄性和雌性大鼠进行。通过酶联免疫吸附测定法（ELISA）测量血清TGF-β水平。
结果
我们的研究结果表明，与对照组相比，雌性成瘾大鼠血清TGF-β的平均水平显著升高（p<0.004）。相反，雄性成瘾大鼠血清TGF-β的平均水平低于对照组（p<0.065）。
结论
我们的结果表明，鸦片及其衍生物对雄性和雌性大鼠细胞因子表达具有不同的诱导作用。
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