在肥胖与减重领域，条条大路通“巨巨噬细胞”。
In obesity and weight loss, all roads lead to the mighty macrophage.
机构信息
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.
出版信息
J Clin Invest. 2010 Oct;120(10):3437-40. doi: 10.1172/JCI44721. Epub 2010 Sep 27.
Abstract
Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.
摘要
肥胖与巨噬细胞浸润白色脂肪组织（WAT）有关，这导致了胰岛素抵抗的发生。在本期 JCI 中，Kosteli 及其同事证明，体重减轻也出乎意料地与巨噬细胞向 WAT 的快速（尽管是短暂的）募集有关，而这似乎与脂肪分解有关。
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