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In obesity and weight loss, all roads lead to the mighty macrophage.
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Lipid signaling in adipose tissue: Connecting inflammation & metabolism.
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CCL5 promotes macrophage recruitment and survival in human adipose tissue.
Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):39-45. doi: 10.1161/ATVBAHA.109.197442. Epub 2009 Nov 5.
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A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice.
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Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019.

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Two-Pronged Attack: Dual Activation of Fat Reduction Using Near-Infrared-Responsive Nanosandwich for Targeted Anti-Obesity Treatment.
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Role of innate lymphoid cells in obesity and metabolic disease (Review).
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Major role of adipocyte prostaglandin E2 in lipolysis-induced macrophage recruitment.
J Lipid Res. 2016 Apr;57(4):663-73. doi: 10.1194/jlr.M066530. Epub 2016 Feb 24.
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Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages.
Front Immunol. 2015 Jan 22;5:683. doi: 10.3389/fimmu.2014.00683. eCollection 2014.
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IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.
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本文引用的文献

1
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue.
J Clin Invest. 2010 Oct;120(10):3466-79. doi: 10.1172/JCI42845. Epub 2010 Sep 27.
2
Control of macrophage activation and function by PPARs.
Circ Res. 2010 May 28;106(10):1559-69. doi: 10.1161/CIRCRESAHA.110.216523.
3
Macrophages, inflammation, and insulin resistance.
Annu Rev Physiol. 2010;72:219-46. doi: 10.1146/annurev-physiol-021909-135846.
5
Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses.
Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):139-43. doi: 10.1161/ATVBAHA.108.179283. Epub 2009 Oct 1.
6
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
Nat Med. 2009 Aug;15(8):914-20. doi: 10.1038/nm.1964. Epub 2009 Jul 26.
7
Normalization of obesity-associated insulin resistance through immunotherapy.
Nat Med. 2009 Aug;15(8):921-9. doi: 10.1038/nm.2001. Epub 2009 Jul 26.

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