男性乳腺黑素细胞性恶性外周神经鞘瘤
Melanocytic Malignant Peripheral Nerve Sheath Tumor of the Male Breast.
作者信息
Wang Haijun, Ge Jing, Chen Lirong, Xie Panpan, Chen Fangfang, Chen Yiding
机构信息
Department of Pathology, The Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang, China.
出版信息
Breast Care (Basel). 2009;4(4):260-262. doi: 10.1159/000229548. Epub 2009 Aug 12.
SUMMARY
BACKGROUND: Malignant peripheral nerve sheath tumors are rare tumor entities that originate from peripheral nerve sheaths and have an unfavorable prognosis. Common sites include deeper soft tissues, usually in the proximity of a nerve trunk. Breast is an absolutely rare location of this lesion, and presentation as a breast lump in the male breast is even rarer. CASE REPORT: A 65-year-old man presented with a 6-month history of a painless mass of the left breast. Tissue biopsy was performed. Histopathology revealed a malignant spindle cell tumor which was confirmed to be a melanocytic malignant peripheral nerve sheath tumor on the basis of immunopositivity for HMB45 and S-100. CONCLUSION: There are no generally accepted guidelines for the treatment of malignant peripheral nerve sheath tumors in the male breast. The patient was referred for radiation therapy after simple mastectomy.
摘要
背景：恶性外周神经鞘瘤是一种罕见的肿瘤实体，起源于外周神经鞘，预后不良。常见部位包括深部软组织，通常靠近神经干。乳腺是该病变极其罕见的部位，在男性乳腺中表现为乳腺肿块则更为罕见。病例报告：一名65岁男性，有左乳无痛性肿块6个月病史。进行了组织活检。组织病理学显示为恶性梭形细胞瘤，基于HMB45和S-100免疫阳性确诊为黑素细胞性恶性外周神经鞘瘤。结论：对于男性乳腺恶性外周神经鞘瘤的治疗，尚无普遍接受的指南。患者在单纯乳房切除术后接受了放射治疗。
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