Zhang Li, Tong Zhongsheng, Li Shufen, Ren Xiubao, Ren Baozhu, Wang Xu, Cao Shui, Wang Chen, He Lihong
Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Breast Care (Basel). 2009;4(6):379-386. doi: 10.1159/000266759. Epub 2009 Dec 28.
As long-term survivors of breast cancer after autologous peripheral blood stem cell transplantation (ASCT) are becoming more numerous, studies addressing the issue of long-term follow-up are necessary. In this study, we report on the quality of life (QOL) after ASCT and high-dose chemotherapy (HDCT). PATIENTS AND METHODS: The QOL questionnaire version 3.0 by the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30 version 3.0) was filled in by patients and healthy controls at 5 time points. After obtaining the results, we analyzed the correlation between QOL and the effect factors. RESULTS: Some functions got significantly worse, and some symptoms got more serious after ASCT and HDCT. However, most of them improved with time and were comparable to the healthy controls after 5 years. QOL was in part related to age, tumor characteristics, educational level, marriage status, and income. CONCLUSIONS: Evaluating QOL allows medical workers to fully understand a patient's state of health, and aid the estimation and selection of clinical treatment methods as well as improve recovery.
随着自体外周血干细胞移植（ASCT）后乳腺癌长期幸存者数量的不断增加，开展长期随访问题的研究很有必要。在本研究中，我们报告了ASCT和大剂量化疗（HDCT）后的生活质量（QOL）。
欧洲癌症研究与治疗组织的生活质量问卷第3.0版（EORTC QLQ-C30第3.0版）由患者和健康对照在5个时间点填写。得出结果后，我们分析了生活质量与影响因素之间的相关性。
ASCT和HDCT后，一些功能显著变差，一些症状变得更严重。然而，它们中的大多数随时间改善，5年后与健康对照相当。生活质量部分与年龄、肿瘤特征、教育水平、婚姻状况和收入有关。
评估生活质量能让医务人员充分了解患者的健康状况，有助于估计和选择临床治疗方法，并促进康复。
