Gu Guo-Li, Wang Shi-Lin, Wei Xue-Ming, Ren Li, Zou Fu-Xian
Department of General Surgery, The General Hospital of Chinese PLA Air Force, Beijing, China.
Breast Care (Basel). 2009;4(1):43-45. doi: 10.1159/000193032. Epub 2009 Feb 20.
BACKGROUND: The aim of this study was to investigate the clinicopathologic features of male breast cancer. CASE REPORT: We present the clinicopathologic data of a 72-year-old male patient with occult breast cancer, who was diagnosed and underwent surgery in our hospital. The diagnosis was confirmed by histological examination, and the patient underwent modified radical mastectomy and axillary dissection. The histological examination showed no tumor foci in the resected breast tissue, but 2 of 15 dissected axillary lymph nodes were invaded by infiltrating ductal carcinoma. Immunohistochemistry staining was negative for both estrogen and progesterone receptors, but showed expression of p53 protein (+++), proliferating cell nuclear antigen (PCNA) (+++), Bcl-2 on-coprotein (+++), nm23 protein (++), multidrug resistance protein (MRP) (++), and human epidermal receptor (HER-2) oncoprotein (+++). 24 months after being diagnosed, the patient is alive without any residual or metastatic disease. CONCLUSIONS: Breast cancer is very rare in men, and the occurrence of occult breast cancer is even less common. Axillary metastases can present as the first manifestation of breast cancer in a male.
背景：本研究旨在调查男性乳腺癌的临床病理特征。病例报告：我们呈现了一名72岁隐匿性乳腺癌男性患者的临床病理资料，该患者在我院确诊并接受手术。诊断经组织学检查证实，患者接受了改良根治性乳房切除术及腋窝淋巴结清扫术。组织学检查显示切除的乳腺组织中无肿瘤病灶，但15枚清扫的腋窝淋巴结中有2枚被浸润性导管癌侵犯。免疫组化染色显示雌激素和孕激素受体均为阴性，但p53蛋白（+++）、增殖细胞核抗原（PCNA）（+++）、Bcl-2原癌蛋白（+++）、nm23蛋白（++）、多药耐药蛋白（MRP）（++）及人表皮受体（HER-2）原癌蛋白（+++）呈阳性表达。确诊24个月后，患者存活，无任何残留或转移病灶。结论：乳腺癌在男性中非常罕见，隐匿性乳腺癌的发生更为少见。腋窝转移可作为男性乳腺癌的首发表现。
