Wang Xinyu, Fan Liwen, Yan Wenxing, Zhang Qi, Bao Shunchao, Wang Ying, Bao Xin, Liu Linlin
Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin Province, China.
Medicine (Baltimore). 2018 Dec;97(50):e13706. doi: 10.1097/MD.0000000000013706.
Occult breast cancer (OBC) is an extremely rare breast cancer and is defined by the presence of axillary metastasis without a primary tumor in the breasts or any abnormality on radiologic examination.
This case report presents a 49-year-old man who was diagnosed with male OBC, which first manifested as an axillary lymph node metastasis followed by the emergence of infraclavicular lymph node metastasis. Neither the breast nor other organs had any abnormality.
The pathological examination revealed metastatic adenocarcinoma. Immunohistochemical (IHC) staining results were positive for estrogen receptor (ER), progesterone receptor (PR), and gross cystic disease fluid protein-15 (GCDFP-15); and negative for human epidermal receptor-2 (Her-2) 1+, cytokeratin (CK) 7, CK20, and thyroid transcription factor-1 (TTF-1).
The patient underwent left axillary lymph node dissection but not a mastectomy. After the operation, the patient subsequently underwent chemotherapy, radiotherapy, and endocrinotherapy.
Currently, he has been followed-up for >4 years without any signs of recurrence.
Careful physical and imaging examinations combined with pathological analysis are essential in the diagnosis of male OBC. Early surgery remains the primary treatment.
隐匿性乳腺癌（OBC）是一种极为罕见的乳腺癌，其定义为腋窝出现转移，而乳房内无原发性肿瘤或影像学检查无任何异常。
本病例报告介绍了一名49岁男性，被诊断为男性OBC，最初表现为腋窝淋巴结转移，随后出现锁骨下淋巴结转移。乳房及其他器官均无异常。
病理检查显示为转移性腺癌。免疫组化（IHC）染色结果显示雌激素受体（ER）、孕激素受体（PR）和乳腺囊肿病液蛋白-15（GCDFP-15）呈阳性；人表皮受体-2（Her-2）1+、细胞角蛋白（CK）7、CK20和甲状腺转录因子-1（TTF-1）呈阴性。
患者接受了左腋窝淋巴结清扫术，但未进行乳房切除术。术后，患者随后接受了化疗、放疗和内分泌治疗。
目前，他已接受随访超过4年，无任何复发迹象。
仔细的体格检查和影像学检查结合病理分析对男性OBC的诊断至关重要。早期手术仍然是主要治疗方法。
