Department of Chemistry, Imperial College London, London, UK SW7 2AZ.
Dalton Trans. 2010 Nov 14;39(42):10056-67. doi: 10.1039/c0dt00815j. Epub 2010 Sep 28.
Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented.
已经合成了三种不同的四氮大环配体，它们都含有四个酰胺取代基，这些取代基具有适合聚合的基团（即烯丙基、苯乙烯基和炔丙基）。这些配体的钆（III）配合物已被制备为潜在的单体，用于合成聚合 MRI 对比剂。为了评估这些单体作为 MRI 对比剂的潜力，已经确定了它们的弛豫增强特性和细胞毒性。还介绍了一种该配体（具有炔丙基取代基）的铕（III）配合物及其 PARACEST 性质。此外，为了更深入地了解四炔丙基取代配体的配位化学，还制备了相应的锌（II）和镉（II）配合物。还介绍了四炔丙基配体及其相应的钆（III）、锌（II）和镉（II）配合物的 X 射线晶体结构。
