Institute of Nuclear Medicine and Allied Sciences, Brig S K. Mazumdar Road, Delhi-54, India.
Dalton Trans. 2011 Apr 7;40(13):3346-51. doi: 10.1039/c0dt01370f. Epub 2011 Feb 23.
A bis-polyazamacrocycle, 10'-bis(acetamido)ethane-bis[1,4,7-tri(carboxymethane)-1,4,7,10-tetraazacyclododecane] (DO3A-AME-DO3A) was synthesized for application in magnetic resonance imaging. The efficacy of DO3A-AME-DO3A as non ionic magnetic contrast agent was tested by performing relaxometric studies on its gadolinium complex. The longitudinal relaxivity, r(1) and transverse relaxivity, r(2) values were found to be 5.84 mM(-1)s(-1) and 6.82 mM(-1)s(-1), per Gd(III) at pH 7.0, 37 °C. The luminescence properties of europium complex of DO3A-AME-DO3A were investigated in aqueous medium. The lifetime of Eu(2)-DO3A-AME-DO3A in water was found to be 0.786 ms. Emission and luminescence lifetime measurements on the europium complex of DO3A-AME-DO3A gives a hydration number of q = 1.9. The reaction enthalpy and entropy were found to be, ΔH(0) = -(6.2 ± 2) kJ mol(-1), ΔS(0) = - (1.8 ± 0.4) kJ mol(-1)K(-1), and K(Eu)(298) = (1.8 ± 0.1).
一种双聚多氮大环化合物，10'-双（乙酰氨基）乙烷双[1,4,7-三（羧甲基）-1,4,7,10-四氮杂环十二烷]（DO3A-AME-DO3A）被合成用于磁共振成像。通过对其钆配合物进行弛豫研究来测试 DO3A-AME-DO3A 作为非离子型磁共振对比剂的功效。在 pH 7.0、37°C 下，每 Gd(III)的纵向弛豫率 r(1)和横向弛豫率 r(2)值分别为 5.84 mM(-1)s(-1)和 6.82 mM(-1)s(-1)。在水介质中研究了 DO3A-AME-DO3A 的铕配合物的发光性质。在水中发现 Eu(2)-DO3A-AME-DO3A 的寿命为 0.786 ms。DO3A-AME-DO3A 的铕配合物的发射和发光寿命测量给出了水合数 q = 1.9。反应焓和熵分别为 ΔH(0) = -(6.2 ± 2) kJ mol(-1)，ΔS(0) = - (1.8 ± 0.4) kJ mol(-1)K(-1)，和 K(Eu)(298) = (1.8 ± 0.1)。
