性别影响 Duchenne 心肌病 mdx 模型中的心脏功能。
Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.
机构信息
Department of Molecular Microbiology and Immunology, School of Medicine, 1 Hospital Drive, Columbia, Missouri 65212, USA.
出版信息
Muscle Nerve. 2010 Oct;42(4):600-3. doi: 10.1002/mus.21763.
Abstract
Aged mdx mice represent an important model for studying Duchenne cardiomyopathy. Herein we compared the cardiac phenotypes of 22-month-old male and female mdx mice. Surprisingly, only females displayed the characteristic cardiac dilation on pressure-volume loop analysis. Female mdx mice also exhibited lower contractility, larger Q waves, and higher ratios of heart weight to body weight. Our results reveal significant gender disparity in mdx cardiac function. Gender should be considered when using the mdx model for the study of Duchenne cardiomyopathy.
摘要
老年 mdx 小鼠是研究杜氏肌营养不良性心肌病的重要模型。在此，我们比较了 22 月龄雄性和雌性 mdx 小鼠的心脏表型。令人惊讶的是，只有雌性在压力-容积环分析中表现出特征性的心脏扩张。雌性 mdx 小鼠还表现出较低的收缩力、较大的 Q 波和更高的心脏重量与体重比。我们的研究结果揭示了 mdx 心脏功能的显著性别差异。在使用 mdx 模型研究杜氏肌营养不良性心肌病时，应考虑性别因素。
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