通过P基因的核苷酸序列区分腮腺炎疫苗株与野病毒。
Differentiation of the mumps vaccine strains from the wild viruses by the nucleotide sequences of the P gene.
作者信息
Yamada A, Takeuchi K, Tanabayashi K, Hishiyama M, Takahashi Y, Sugiura A
机构信息
Department of Measles Virus, National Institute of Health, Tokyo, Japan.
出版信息
Vaccine. 1990 Dec;8(6):553-7. doi: 10.1016/0264-410x(90)90007-9.
Nucleotide sequence analysis of a part of the P gene of mumps virus allowed the differentiation of live attenuated mumps vaccine strains from each other and from wild mumps viruses. Restriction enzyme analysis was found to serve as a convenient method of screening for one strain of mumps vaccine. Examination by the method of virus isolates obtained from the patients who developed mumps parotitis or meningitis following vaccination revealed that most of those viruses were related to the respective vaccine viruses used for immunization.
对腮腺炎病毒P基因部分进行核苷酸序列分析，可区分减毒活腮腺炎疫苗株彼此之间以及与野生腮腺炎病毒的差异。限制性内切酶分析被发现是筛选一种腮腺炎疫苗株的便捷方法。通过对接种疫苗后发生腮腺炎性腮腺炎或脑膜炎的患者所获得的病毒分离株进行检测发现，这些病毒大多与用于免疫的相应疫苗病毒有关。
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