Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour University,Sagar-470 003, India.
Drug Deliv. 2010 Nov;17(8):605-16. doi: 10.3109/10717544.2010.509359.
Proteins and peptides are complex macromolecules that are prone to change in their native structure during storage, which causes undesired side-effects after their administration. During past decades, bioactive carriers have played an important role in stabilization of proteins. Incorporation of the protein and peptides into a particulate carrier can protect it against degradation in vitro and in vivo, the release can be controlled,and it also offers possibilities for targeting. This review has focused on a wide range of bioactive carriers used in protein stabilization during long time storage. Bioactive carriers can protect the bioactives from degradation, resulting in increased bioavailability of protein.
蛋白质和肽类是复杂的大分子，在储存过程中容易改变其天然结构，从而导致给药后产生不良的副作用。在过去几十年中，生物活性载体在蛋白质的稳定化方面发挥了重要作用。将蛋白质和肽类掺入颗粒载体中可以保护其免受体外和体内的降解，还可以控制释放，并提供靶向的可能性。本综述重点介绍了在长时间储存过程中用于蛋白质稳定化的各种生物活性载体。生物活性载体可以保护生物活性物质不被降解，从而提高蛋白质的生物利用度。
