Yamashita Takuya, Yamashita Kohei, Nabeshi Hiromi, Yoshikawa Tomoaki, Yoshioka Yasuo, Tsunoda Shin-Ichi, Tsutsumi Yasuo
Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.
Materials (Basel). 2012 Feb 21;5(2):350-363. doi: 10.3390/ma5020350.
Carbon nanomaterials, including fullerenes, carbon nanohorns, and carbon nanotubes, are increasingly being used in various fields owing to these materials' unique, size-dependent functions and physicochemical properties. Recently, because of their high variability and stability, carbon nanomaterials have been explored as a novel tool for the delivery of therapeutic molecules including peptide and nucleic acid cancer drugs. However, insufficient information is available regarding the safety of carbon nanomaterials for human health, even though such information is vital for the development of safe and effective nanomedicine technologies. In this review, we discuss currently available information regarding the safety of carbon nanomaterials in nanomedicine applications, including information obtained from our own studies; and we discuss types of carbon nanomaterials that demonstrate particular promise for safe nanomedicine technologies.
碳纳米材料，包括富勒烯、碳纳米角和碳纳米管，由于其独特的、尺寸依赖性的功能和物理化学性质，越来越多地应用于各个领域。最近，由于其高变异性和稳定性，碳纳米材料已被探索作为一种新型工具，用于递送包括肽和核酸癌症药物在内的治疗性分子。然而，关于碳纳米材料对人类健康的安全性，即使这些信息对于安全有效的纳米医学技术的发展至关重要，目前仍缺乏足够的信息。在这篇综述中，我们讨论了目前关于碳纳米材料在纳米医学应用中的安全性的可用信息，包括从我们自己的研究中获得的信息；并且我们讨论了对安全纳米医学技术具有特别前景的碳纳米材料类型。
