Zhang B H, Wang N S, Li X J, Kong X J, Cai Y L
Department of Pharmacology, College of Basic Medicine, Beijing Medical University, China.
Zhongguo Yao Li Xue Bao. 1990 May;11(3):253-7.
Matrine (MT) is an alkaloid isolated from Sophra alopecuroids L. The LD50 of MT iv to mice was 72.1 mg/kg (95% CL 68.2-76.5 mg/kg). MT had significant effects on different experimental models of arrhythmias induced by aconitine, barium chloride or coronary ligation. The ECG of anesthetized rats was significantly changed after iv of MT. The HR was retarded and the PR and QTc intervals were prolonged.
苦参碱（MT）是从苦豆子中分离出的一种生物碱。MT静脉注射对小鼠的半数致死量为72.1毫克/千克（95%可信区间为68.2 - 76.5毫克/千克）。MT对乌头碱、氯化钡或冠状动脉结扎诱导的不同心律失常实验模型有显著影响。静脉注射MT后，麻醉大鼠的心电图发生显著变化。心率减慢，PR间期和QTc间期延长。
