University of Oxford, OCDEM, Churchill Hospital, Oxford, Oxfordshire, UK.
Diabetes Obes Metab. 2010 Nov;12(11):941-6. doi: 10.1111/j.1463-1326.2010.01256.x.
The global incidence and prevalence of obesity continue to increase, with the fastest rate of increase in the developing world. Obesity is associated with many chronic diseases including type 2 diabetes, cardiovascular disease and some cancers. Weight loss can reduce the risk of developing these diseases and can be achieved by means of surgery, pharmacotherapy and lifestyle interventions. Lifestyle interventions for prevention and treatment of obesity include diet, exercise and psychological interventions. All lifestyle interventions have a modest but significant effect on weight loss, but there is little evidence to indicate that any one intervention is more effective. There is evidence of an additive effect for adjunct therapy, and the combination of diet, exercise and behavioural interventions appears to be most effective for both the prevention and treatment of obesity.
全球肥胖的发病率和患病率持续上升，发展中国家的增长速度最快。肥胖与许多慢性疾病有关，包括 2 型糖尿病、心血管疾病和某些癌症。减肥可以降低这些疾病的发病风险，可以通过手术、药物治疗和生活方式干预来实现。预防和治疗肥胖的生活方式干预包括饮食、运动和心理干预。所有生活方式干预对减肥都有适度但显著的效果，但几乎没有证据表明任何一种干预更有效。辅助治疗有累加效应，饮食、运动和行为干预的联合似乎对肥胖的预防和治疗最有效。
