Wei Hui-jie, Jiang Rong-cai, Liu Li, Zhang Jian-ning
Department of Neurosurgery, General Hospital, Tianjin Medical University, Tianjin 300052, China.
Chin J Traumatol. 2010 Oct 1;13(5):316-8.
Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the world. Recent clinical investigations and basic researches suggest that strategies to improve angiogenesis following TBI may provide promising opportunities to improve clinical outcomes and brain functional recovery. More and more evidences show that circulating endothelial progenitor cells (EPCs), which have been identified in the peripheral blood, may play an important role in the pathologic and physiological angiogenesis in adults. Moreover, impressive data demonstrate that EPCs are mobilized from bone marrow to blood circulation in response to traumatic or inflammatory stimulations. In this review, we discussed the role of EPCs in the repair of brain injury and the possible therapeutic implication for functional recovery of TBI in the future.
创伤性脑损伤（TBI）是全球范围内致死和致残的主要原因。近期的临床研究和基础研究表明，改善创伤性脑损伤后血管生成的策略可能为改善临床结局和脑功能恢复提供有前景的机会。越来越多的证据表明，在外周血中已被鉴定出的循环内皮祖细胞（EPCs）可能在成体的病理和生理血管生成中发挥重要作用。此外，令人瞩目的数据表明，EPCs会响应创伤或炎症刺激从骨髓动员至血液循环。在本综述中，我们讨论了EPCs在脑损伤修复中的作用以及未来对创伤性脑损伤功能恢复可能的治疗意义。
