Li R Y, Lin S Y, Zhang T Z
Department of Radiotherapy and Radiation physics, Tianjin Cancer Institute, China.
Adv Exp Med Biol. 1990;267:521-3. doi: 10.1007/978-1-4684-5766-7_56.
During 1980 to 1983, 40 patients with advanced or locally recurrent breast cancer were treated with the thermo-radiotherapy. Ten of these were primary cases and 30 recurrent. In 23 patients who had 2 to 3 lesions. Altogether there were 64 lesions treated. Combined thermo-radiotherapy was applied to the bigger lesions (42 in number) and irradiation alone to the small ones (22 in number). Average size of lesions treated with combined therapy was 38.7 cm2 and that by irradiation alone was 12.1 cm2. In 20 patients of this series previous irradiation (40-65 Gy) were given. Hyperthermia was given by using microwave 2450 MHz and 915 MHz, twice a week, 15-30 minutes following irradiation. Intratumoral temperature was maintained at 41-44 degrees C for 40 minutes. A average of 11.6 sessions of heat was given. Radiotherapy was given after conventional freactionation technic 2-2.5 Gy/day x 4-5/week to reach a total dosage of 20-80 Gy (average 47 Gy). Notwithstanding the size of tumor treated with combined therapy was 2 to 3 times larger than that treated by radiotherapy alone, the CR rate, of lesions after combined therapy was significantly better than radiation alone, 64.3% V.S. 36.4% (P less than 0.01). The authors believe that the optimal size of tumor for hyperthermia using microwave 2450 MHz or 915 MHz may be less than 5-6 in diameter.
1980年至1983年期间，40例晚期或局部复发性乳腺癌患者接受了热放疗。其中10例为原发性病例，30例为复发性病例。23例患者有2至3个病灶。总共治疗了64个病灶。对较大的病灶（共42个）采用热放疗联合治疗，对较小的病灶（共22个）仅采用放疗。联合治疗的病灶平均大小为38.7平方厘米，单纯放疗的病灶平均大小为12.1平方厘米。该系列中的20例患者此前接受过放疗（40 - 65 Gy）。使用2450 MHz和915 MHz的微波进行热疗，每周两次，放疗后15 - 30分钟，瘤内温度维持在41 - 44摄氏度40分钟，平均进行11.6次热疗。放疗采用常规分割技术，每天2 - 2.5 Gy，每周4 - 5次，总剂量达到20 - 80 Gy（平均47 Gy）。尽管联合治疗的肿瘤大小比单纯放疗的肿瘤大2至3倍，但联合治疗后病灶的完全缓解率明显优于单纯放疗，分别为64.3%和36.4%（P小于0.01）。作者认为，使用2450 MHz或915 MHz微波进行热疗的最佳肿瘤直径可能小于5 - 6厘米。
