Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, Oslo, Norway.
Trends Cell Biol. 2010 Nov;20(11):642-9. doi: 10.1016/j.tcb.2010.08.010. Epub 2010 Sep 27.
Cytokinesis is the final step of cell division whereby the dividing cells separate physically. Failure of this process has been proposed to cause tumourigenesis. Several specific lipids are essential for cytokinesis, and recent evidence has revealed that phosphatidylinositol 3-phosphate (PtdIns3P) - a well-known regulator of endosomal trafficking, receptor signaling, nutrient sensing and autophagy - plays an evolutionarily conserved role during cytokinesis. The emerging picture is that PtdIns3P and its regulators and effectors constitute a novel regulatory mechanism for cytokinesis. Elucidating the role of PtdIns3P in cytokinesis might contribute to insight into mechanisms of tumour development and suppression.
胞质分裂是细胞分裂的最后一步，在此过程中，分裂的细胞会彼此分离。据推测，这一过程的失败会导致肿瘤发生。有几种特定的脂质对胞质分裂至关重要，最近的证据表明，磷脂酰肌醇 3-磷酸（PtdIns3P）——一种众所周知的内体运输、受体信号转导、营养感应和自噬的调节剂——在胞质分裂过程中起着进化保守的作用。目前的情况是，PtdIns3P 及其调节因子和效应因子构成了胞质分裂的一种新的调控机制。阐明 PtdIns3P 在胞质分裂中的作用可能有助于深入了解肿瘤发生和抑制的机制。
