Campa Carlo C, Martini Miriam, De Santis Maria C, Hirsch Emilio
Department of Molecular Biotechnology and Health Sciences, University of Turin Torino, Italy.
Front Cell Dev Biol. 2015 Sep 30;3:61. doi: 10.3389/fcell.2015.00061. eCollection 2015.
To succeed in cell division, intense cytoskeletal and membrane remodeling are required to allow accurate chromosome segregation and cytoplasm partitioning. Spatial restriction of the actin dynamics and vesicle trafficking define the cell symmetry and equivalent membrane scission events, respectively. Protein complexes coordinating mitosis are recruited to membrane microdomains characterized by the presence of the phosphatidylinositol lipid members (PtdIns), like PtdIns(3,4,5)P 3,PtdIns(4,5)P 2, and PtdIns(3)P. These PtdIns represent a minor component of cell membranes, defining membrane domain identity, ultimately controlling cytoskeleton and membrane dynamics during mitosis. The coordinated presence of PtdIns(3,4,5)P 3 at the cell poles and PtdIns(4,5)P 2 at the cleavage furrow controls the polarity of the actin cytoskeleton leading to symmetrical cell division. In the endosomal compartment, the trafficking of PtdIns(3)P positive vesicles allows the recruitment of the protein machinery required for the abscission.
为了成功进行细胞分裂，需要强烈的细胞骨架和膜重塑，以实现准确的染色体分离和细胞质分配。肌动蛋白动力学和囊泡运输的空间限制分别定义了细胞对称性和等效的膜分裂事件。协调有丝分裂的蛋白质复合物被招募到以磷脂酰肌醇脂质成员（PtdIns）存在为特征的膜微区，如PtdIns(3,4,5)P 3、PtdIns(4,5)P 2和PtdIns(3)P。这些PtdIns代表细胞膜的一小部分，定义膜结构域身份，最终在有丝分裂期间控制细胞骨架和膜动力学。PtdIns(3,4,5)P 3在细胞两极和PtdIns(4,5)P 2在分裂沟的协同存在控制肌动蛋白细胞骨架的极性，导致细胞对称分裂。在内体区室中，PtdIns(3)P阳性囊泡的运输允许募集分裂所需的蛋白质机制。
Zotero 插件