成人囊性纤维化人群中的掌多汗症性皱纹。
Aquagenic wrinkling of the palms in an adult cystic fibrosis population.
机构信息
Department of Dermatology, Ulster Hospital, Dundonald, Belfast, UK.
出版信息
Dermatology. 2010;221(4):326-30. doi: 10.1159/000319754. Epub 2010 Sep 25.
BACKGROUND
Aquagenic wrinkling of the palms (AWP) is a rare condition characterised by the development of oedema and excessive wrinkling of the palms following exposure to water. It has frequently been associated with cystic fibrosis (CF). Early reports of AWP have only been case reports or small case series; there has only been one reported prevalence study of AWP in a CF population.
OBJECTIVE
To determine the incidence and characteristics of AWP in the adult CF population in Northern Ireland.
METHODS
105 CF patients were interviewed. The patients were asked whether they noticed excess wrinkling of the hands when exposed to water. If they answered 'yes', further questions were asked regarding clinical characteristics. The atopic status, CF genotype and drug history were recorded for each patient. Formal testing of 7 patients was carried out.
RESULTS
Out of the 105 patients who were interviewed, 43 (41%) described AWP. Of the 43 patients with AWP, 20 were male and 23 were female. There was no association of AWP with genotype, atopy or concomitant drug intake.
CONCLUSION
AWP appears to have an equal sex incidence, and the high number of cases in the population studied would suggest that this condition is underreported.
背景
水诱发性手掌皱褶（AWP）是一种罕见的病症，其特征是手掌在接触水后出现水肿和过度皱褶。它常与囊性纤维化（CF）有关。早期关于 AWP 的报告仅是病例报告或小病例系列；仅有一项关于 CF 人群中 AWP 的患病率研究报告。
目的
确定北爱尔兰成年 CF 人群中 AWP 的发病率和特征。
方法
对 105 名 CF 患者进行了访谈。询问患者在接触水时是否注意到手部过度皱褶。如果回答“是”，则进一步询问其临床特征。记录每位患者的特应性状态、CF 基因型和药物史。对 7 名患者进行了正式测试。
结果
在接受访谈的 105 名患者中，有 43 名（41%）描述了 AWP。在 43 名患有 AWP 的患者中，有 20 名男性和 23 名女性。AWP 与基因型、特应性或同时服用的药物之间没有关联。
结论
AWP 的性别发病率似乎相等，而研究人群中大量的病例表明这种情况被低估了。
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