硝哒唑酮 A 和 B：来自Pulmonaria 属海鞘的新型生物活性生物碱。

Synoxazolidinones A and B: novel bioactive alkaloids from the ascidian Synoicum pulmonaria.

机构信息

Norwegian College of Fishery Science, University of Tromsø, Breivika N-9037, Tromsø, Norway.

出版信息

Org Lett. 2010 Nov 5;12(21):4752-5. doi: 10.1021/ol101707u.

PMID:20883040

Abstract

Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.

摘要

基于生物活性的导向分离，从挪威海域采集的亚热带海鞘中分离得到了一种新型的溴化胍基恶唑烷酮类化合物，命名为 synoxazolidinones A 和 B（1 和 2）。这些化合物的骨架中含有一个在天然产物中很少见的 4-恶唑烷酮环。通过光谱方法确定了化合物的结构。这些 synoxazolidinones 表现出抗菌和抗真菌活性。