Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea.
Bioorg Med Chem. 2012 Jul 1;20(13):4082-7. doi: 10.1016/j.bmc.2012.05.002. Epub 2012 May 11.
Six β-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y(1) (7) and six new derivatives, designated eudistomins Y(8)-Y(13) (8-13). Several of these natural and synthetic compounds exhibited moderate to significant antimicrobial activity, weak cytotoxic activity, and inhibitory activities toward sortase A, isocitrate lyase, and Na(+)/K(+)-ATPase. Structure-activity relationships were also deduced.
从韩国海鞘 Synoicum sp. 中分离得到了 6 种β-咔啉生物碱（1-6），属于 eudistomin Y 类。这些化合物经化学转化为已知化合物 eudistomin Y(1)（7）和 6 种新衍生物，分别命名为 eudistomins Y(8)-Y(13)（8-13）。这些天然和合成化合物中的几种表现出中等至显著的抗菌活性、弱细胞毒性活性以及对 sortase A、异柠檬酸裂解酶和 Na(+)/K(+)-ATPase 的抑制活性。还推导出了构效关系。
