N3-芳基螺咪唑烷-2,4-二酮、N3-芳基螺咪唑烷-2-硫代-4-酮及4-羟基衍生物。合成与驱虫活性
N3-arylspiroimidazolidine-2,4-diones N3-arylspiroimidazolidine-2-thio-4-ones and 4-hydroxy derivatives. Synthesis and anthelmintic activity.
作者信息
Espada M, Pedregal C, Alonso A, López C, Salazar L, Martinez M M, Guillén J L, Martinez A R
机构信息
Dpto. de Quimica Orgánica y Farmacéuticia, Facultad de Farmacia, Universidad Complutense, Madrid, España.
出版信息
Farmaco. 1990 Nov;45(11):1237-43.
PMID:2088366
Abstract
The synthesis of new N3-arylciclohexanespiroimidazolidine-2,4-diones, N3-arylciclohexanespiroimidazolidine-2-tio-4-ones and the 4-hydroxy derivatives is described and their structures discussed on the basis of I.R. and 1H-N.R.M. data. The anthelmintic activity of these compounds was tested.
摘要
描述了新型N3-芳基环己烷螺咪唑啉-2,4-二酮、N3-芳基环己烷螺咪唑啉-2-硫代-4-酮及其4-羟基衍生物的合成，并根据红外光谱和1H-核磁共振数据对其结构进行了讨论。测试了这些化合物的驱虫活性。
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