新型系列4-[2'-(6'-硝基)苯并咪唑基]苯甲酰基氨基酸和肽的合成及生物活性
Synthesis and biological activity of a novel series of 4-[2'-(6'-nitro)benzimidazolyl]benzoyl amino acids and peptides.
作者信息
Himaja M, Ramana M V, Poojary Boja, Satyanarayana D, Subrahmanyam E V, Bhat K Ishwar
机构信息
NGSM Institute of Pharmaceutical Sciences, Nanthoor, Mangalore, India.
出版信息
Boll Chim Farm. 2003 Dec;142(10):450-3.
PMID:14971314
Abstract
A series of new 4-[2'-(6'-nitro)benzimidazolyl]benzoyl amino acids and peptides have been synthesized by coupling the 4-[2'-(6'-nitro)benzimidazolyl]benzoic acid with amino acid methyl esters/dipeptides using DCC as the coupling agent. All the synthesized compounds were found to exhibit potent anthelmintic activity along with moderate antimicrobial activity.
摘要
通过使用二环己基碳二亚胺（DCC）作为偶联剂，将4-[2'-(6'-硝基)苯并咪唑基]苯甲酸与氨基酸甲酯/二肽偶联，合成了一系列新的4-[2'-(6'-硝基)苯并咪唑基]苯甲酰基氨基酸和肽。发现所有合成的化合物都表现出强效驱虫活性以及适度的抗菌活性。
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