Albuquerque J F, Albuquerque A, Azevedo C C, Thomasson F, Galdino L S, Chantegrel J, Catanho M T, Pitta I R, Luu-Duc C
Departamento de Antibiotics, Universidade Federal de Pernambuco, Recife, Brésil.
Pharmazie. 1995 Jun;50(6):387-9.
Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.
描述了六种3-(4-溴苯甲酰基)-5-亚芳基-噻唑烷-2,4-二酮和八种3-(4-氯苄基)-5-亚芳基-4-硫代-咪唑烷-2-酮的合成及其物理化学性质。这些产物是通过芳香醛与3-取代的噻唑烷-2,4-二酮或4-硫代-咪唑烷-2-酮的羟醛缩合-巴豆酰化反应合成的。对这些化合物的降血糖和外周抗伤害感受活性进行了研究。
