Max F. Perutz Laboratories, Medical University of Viena, A-1030 Viena, Austria.
Plant Cell. 2010 Sep;22(9):2926-9. doi: 10.1105/tpc.110.078352. Epub 2010 Sep 30.
Growing interest in alternative splicing in plants and the extensive sequencing of new plant genomes necessitate more precise definition and classification of genes coding for splicing factors. SR proteins are a family of RNA binding proteins, which function as essential factors for constitutive and alternative splicing. We propose a unified nomenclature for plant SR proteins, taking into account the newly revised nomenclature of the mammalian SR proteins and a number of plant-specific properties of the plant proteins. We identify six subfamilies of SR proteins in Arabidopsis thaliana and rice (Oryza sativa), three of which are plant specific. The proposed subdivision of plant SR proteins into different subfamilies will allow grouping of paralogous proteins and simple assignment of newly discovered SR orthologs from other plant species and will promote functional comparisons in diverse plant species.
人们对植物中可变剪接的兴趣日益浓厚,新的植物基因组测序也在不断增加,这就需要更精确地定义和分类编码剪接因子的基因。SR 蛋白是一类 RNA 结合蛋白,是组成性和可变剪接的必需因子。我们提出了一种植物 SR 蛋白的统一命名法,同时考虑了哺乳动物 SR 蛋白的最新修订命名法以及植物蛋白的一些特有性质。我们在拟南芥和水稻中鉴定出了 6 种 SR 蛋白亚家族,其中 3 种是植物特有的。将植物 SR 蛋白划分为不同的亚家族,将有助于对同源蛋白进行分类,并简单地将其他植物物种中新发现的 SR 直系同源物进行归类,从而促进不同植物物种中的功能比较。