Bischel O E, Böhm P M
Orthopaedic University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.
J Bone Joint Surg Br. 2010 Oct;92(10):1435-41. doi: 10.1302/0301-620X.92B10.24024.
Endoprosthetic reconstruction following resection of 31 tumours of the proximal femur in 30 patients was performed using a Wagner SL femoral revision stem. The mean follow-up was 25.6 months (0.6 to 130.0). Of the 28 patients with a metastasis, 27 died within a mean follow-up period of 18.1 months (0.6 to 56.3) after the operation, and the remaining patient was excluded from the study 44.4 months post-operatively when the stem was removed. The two patients with primary bone tumours were still alive at the latest follow-up of 81.0 and 130.0 months, respectively. One stem only was removed for suspected low-grade infection 44.4 months post-operatively. The worst-case survival rate with removal of the stem for any cause and/or loss to follow-up was 80.0% (95% confidence interval 44.9 to 100) at 130.0 months. The mean Karnofsky index increased from 44.2% (20% to 70%) pre-operatively to 59.7% (0% to 100%) post-operatively, and the mean Merle d'Aubigné score improved from 4.5 (0 to 15) to 12.0 (0 to 18). The mean post-operative Musculoskeletal Tumour Society score was 62.4% (3.3% to 100%). The Wagner SL femoral revision stem offers an alternative to special tumour prostheses for the treatment of primary and secondary tumours of the proximal femur. The mid-term results are very promising, but long-term experience is necessary.
采用Wagner SL股骨翻修柄对30例患者的31处股骨近端肿瘤切除后进行了人工关节置换重建。平均随访时间为25.6个月(0.6至130.0个月)。28例有转移的患者中,27例在术后平均18.1个月(0.6至56.3个月)的随访期内死亡,其余1例患者在术后44.4个月取出假体柄时被排除在研究之外。2例原发性骨肿瘤患者在最新随访时分别存活81.0个月和130.0个月。仅1例假体柄在术后44.4个月因疑似低度感染而被取出。在130.0个月时,因任何原因取出假体柄和/或失访的最坏情况生存率为80.0%(95%置信区间44.9至100)。卡诺夫斯基指数平均从术前的44.2%(20%至70%)提高到术后的59.7%(0%至100%),Merle d'Aubigné评分平均从4.5(0至15)提高到12.0(0至18)。术后肌肉骨骼肿瘤学会评分平均为62.4%(3.3%至100%)。Wagner SL股骨翻修柄为治疗股骨近端原发性和继发性肿瘤提供了一种特殊肿瘤假体的替代方案。中期结果很有前景,但仍需要长期经验。