肿瘤发生：Twist1 将 EMT 与自我更新联系起来。
Tumorigenesis: Twist1 links EMT to self-renewal.
出版信息
Nat Cell Biol. 2010 Oct;12(10):924-5. doi: 10.1038/ncb1010-924.
PMID:20885418
Abstract
The epithelial-mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.
摘要
上皮-间充质转化（EMT）发生在转移性前癌细胞中，并且与获得干细胞样特征有关。现在，EMT 和干细胞之间的分子联系已经出现，研究发现多梳蛋白 Bmi1 是一种促进某些干细胞群体自我更新的蛋白，它是 EMT 诱导剂 Twist1 的直接转录靶标。
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