CARE Hospitals Hyderabad, India.
Int J Cardiol. 2012 Jan 26;154(2):163-7. doi: 10.1016/j.ijcard.2010.09.016. Epub 2010 Oct 2.
Epidemiology of sudden cardiac death (SCD) in India is understudied.
We assessed proportion of SCD among total mortality in a population in Southern India using a staged, questionnaire-based kindred-wide approach. Detailed questionnaires (DQs) were completed by medical trainees from 8 medical colleges. Preliminary questionnaires evaluated total deaths in the kindred of a respondent. Deaths due to obvious non-cardiac causes were excluded. DQs were completed for the remaining deaths and categorized using a three-member adjudication system.
A total population of 22,724 was evaluated by 478 respondents, (278 M and 200 F). Out of a total of 2185 deaths, 1691 (77.4%) were recallable. A total of 173 (10.3%; 128 M and 45 F; mean age - 60.8 ± 14 years) deaths were adjudicated as SCD. Of these, 82 (47.3%) were ≤ 60 years of age. Prior MI, LV dysfunction and prior aborted SCD were found in 33.5%, 22.5% and 5.7% respectively. Coronary artery disease (CAD) was observed in 66 (38%) and acute myocardial infarction documented in 30 (17%). At least 1 of 3 CAD risk factors - hypertension, diabetes, or smoking was observed in 80.6%. Proportion of subjects with at least one risk factor for CAD were similar in the age groups above and below 50 years (67.6% vs. 81.7%, p=0.065).
SCD contributed to 10.3% of overall mortality in this population from Southern India. On an average, SCD cases were 5-8 years younger compared to populations reported in the western hemisphere, with a high prevalence of major risk factors for CAD.
印度的心脏性猝死（SCD）流行病学研究较少。
我们采用分阶段、基于问卷的家系广泛方法，评估了印度南部某人群中心源性猝死在总死亡率中的比例。8 所医学院的医学生完成了详细问卷（DQ）。初步问卷评估了受访者亲属中的总死亡人数。排除明显非心脏原因导致的死亡。对于其余死亡病例，完成 DQ 并使用三人裁决系统进行分类。
共有 478 名受访者评估了 22724 人，其中 278 人为男性，200 人为女性。2185 例死亡中有 1691 例（77.4%）可追溯。共有 173 例（10.3%；128 例为男性，45 例为女性；平均年龄 60.8 ± 14 岁）死亡被判定为 SCD。其中，82 例（47.3%）年龄≤60 岁。33.5%的患者有先前的心肌梗死、左心室功能障碍和先前的心脏骤停史，22.5%和 5.7%的患者分别有冠状动脉疾病（CAD）和急性心肌梗死。66 例（38%）存在 CAD，30 例（17%）有急性心肌梗死的记录。至少有 1 项 CAD 危险因素——高血压、糖尿病或吸烟在 80.6%的患者中存在。年龄大于或小于 50 岁的患者中，至少有一项 CAD 危险因素的患者比例相似（67.6%比 81.7%，p=0.065）。
在印度南部的该人群中，SCD 占总死亡率的 10.3%。平均而言，SCD 患者比西半球报道的人群年轻 5-8 岁，且 CAD 的主要危险因素普遍存在。
