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利用 QFT-Leishmania 作为评估利什曼原虫感染暴露的流行病学工具。

Quantiferon-Leishmania as an epidemiological tool for evaluating the exposure to Leishmania infection.

机构信息

Department of Parasitology, Ege University Medical School, Izmir, Turkey.

出版信息

Am J Trop Med Hyg. 2010 Oct;83(4):822-4. doi: 10.4269/ajtmh.2010.09-0605.

DOI:10.4269/ajtmh.2010.09-0605
PMID:20889872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2946749/
Abstract

The aim of the present preliminary study was to investigate the potential of measurement of IFN-γ secretion by T cells into blood plasma using QuantiFERON assay with leishmanial antigens to determine the presence of Leishmania infection. Blood samples from cured visceral (N = 18), and cutaneous (N = 20) leishmaniasis cases, and 20 healthy controls were tested. The IFN-γ responses to Leishmania major H2B and Leishmania infantum H2B antigens were detected from the majority of treated old visceral leishmaniasis cases, but not from controls. Future studies using larger groups will be required to establish the true potential of the assay for epidemiological screening of leishmaniasis.

摘要

本初步研究的目的是探讨使用利什曼原虫抗原的 QuantiFERON 测定法测量 T 细胞向血浆中分泌 IFN-γ 的潜力，以确定是否存在利什曼原虫感染。检测了 18 例已治愈的内脏（N=18）和 20 例皮肤（N=20）利什曼病病例以及 20 名健康对照者的血液样本。从大多数经治疗的陈旧性内脏利什曼病病例中检测到了针对利什曼原虫 H2B 和利什曼原虫 H2B 抗原的 IFN-γ 反应，但对照组没有。需要使用更大的群体进行未来的研究，以确定该检测法在利什曼病流行病学筛查中的真正潜力。

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本文引用的文献

[1]
T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings.

Curr Opin Pulm Med. 2009-5

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Clin Diagn Lab Immunol. 2001-3

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