解析可卡因成瘾中脑源性神经营养因子-长时程增强效应的耦合关系
Decoding BDNF-LTP coupling in cocaine addiction.
作者信息
Mao Li-Min, Fibuch Eugene E, Wang John Q
机构信息
Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
出版信息
Neuron. 2010 Sep 9;67(5):679-681. doi: 10.1016/j.neuron.2010.08.036.
Abstract
BDNF is a neurotrophic peptide that regulates synaptic plasticity. New work by Lu and coworkers in this issue of Neuron now identifies BDNF as a gatekeeper of synaptic and behavioral plasticity in cocaine sensitization. In the medial prefrontal cortex, upregulated BDNF facilitates LTP and contributes to neurobehavioral adaptations to psychostimulants.
摘要
脑源性神经营养因子（BDNF）是一种调节突触可塑性的神经营养肽。陆及其同事在本期《神经元》杂志上发表的新研究现已确定BDNF是可卡因致敏中突触和行为可塑性的守门人。在内侧前额叶皮层中，上调的BDNF促进长时程增强（LTP），并有助于对精神兴奋剂产生神经行为适应性变化。
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