State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, 5 Xinmofan Road, Nanjing, 210009, People's Republic of China.
J Mater Sci Mater Med. 2010 Dec;21(12):3065-76. doi: 10.1007/s10856-010-4160-z. Epub 2010 Oct 2.
Anti-washout CaF(2) stabilized C(3)S (F-C(3)S) bone cement was prepared by adding water-soluble carboxymethyl chitosan (CMCS) to the hydration liquid. The setting time, compressive strength and in vitro bioactivity of the CMCS modified F-C(3)S (CMCS-C(3)S) pastes were evaluated. The results indicate that CMCS-C(3)S pastes could be stable in the shaking simulated body fluid (SBF) after immediately mixed. The addition of CMCS significantly enhances the cohesion of particles, at the same time restrains the penetration of liquid, and thus endows the anti-washout ability. The setting times of the pastes increase with the increase of CMCS concentrations in the hydration liquid. Besides, the compressive strengths of CMCS-C(3)S pastes after setting for 1-28 days are lower than that of the pure F-C(3)S paste, but the sufficient strengths would be suitable for the clinical applications. The crystalline apatite deposited on the paste surface is retarded from 1 to 2 days for the addition of CMCS, but the quantities of deposited apatite are same after soaking in SBF for 3 days. As the result that pure C(3)S paste has shorter setting times than pure F-C(3)S paste, CMCS modified pure C(3)S pastes would have better anti-washout ability. Our study provides a convenient way to use C(3)S bone cement with excellent anti-washout ability when the pastes are exposed to biological fluids. The novel anti-washout CMCS-C(3)S bone cement with suitable setting times, sufficient strengths and in vitro bioactivity would have good prospects for medical application.
抗冲洗 CaF(2)稳定的 C(3)S（F-C(3)S）骨水泥是通过在水化液中添加水溶性羧甲基壳聚糖（CMCS）制备的。评价了 CMCS 改性 F-C(3)S（CMCS-C(3)S）糊剂的凝固时间、抗压强度和体外生物活性。结果表明，CMCS-C(3)S 糊剂在立即混合后可在摇动模拟体液（SBF）中稳定。CMCS 的添加显著增强了颗粒的内聚性，同时抑制了液体的渗透，从而赋予了抗冲洗能力。糊剂的凝固时间随水化液中 CMCS 浓度的增加而增加。此外，CMCS-C(3)S 糊剂在凝固 1-28 天后的抗压强度低于纯 F-C(3)S 糊剂，但足够的强度适用于临床应用。在添加 CMCS 的情况下，沉积在糊剂表面的结晶磷灰石从 1 天延迟到 2 天，但在 SBF 浸泡 3 天后沉积的磷灰石量相同。由于纯 C(3)S 糊剂的凝固时间短于纯 F-C(3)S 糊剂，因此 CMCS 改性的纯 C(3)S 糊剂具有更好的抗冲洗能力。我们的研究为在暴露于生物流体时使用具有优异抗冲洗能力的 C(3)S 骨水泥提供了一种简便的方法。新型抗冲洗 CMCS-C(3)S 骨水泥具有合适的凝固时间、足够的强度和体外生物活性，具有良好的医疗应用前景。
