Classen W, Laux G
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
J Neural Transm Suppl. 1990;32:185-8. doi: 10.1007/978-3-7091-9113-2_27.
Two groups of depressed patients were treated either with a selective MAO-A-inhibitor, moclobemide (n = 13) or a tetracyclic antide-pressant, maprotiline (n = 18), in a 28 days lasting double blind investigation. Before and after treatment psychopathologic symptoms were rated, motor performance was proven, and acoustic and visual sensomotoric performance were investigated. Deterioration of psychomotor performance were seen in patients without amelioration of their psychopathologic symptoms, especially when treated with moclobemide. These findings were regarded as a hint that possibly the therapeutic agent interacts with the wrong transmitter system and perhaps this is the reason for the deterioration of psychomotor functions.
在一项为期28天的双盲研究中，两组抑郁症患者分别接受选择性单胺氧化酶A抑制剂吗氯贝胺（n = 13）或四环类抗抑郁药马普替林（n = 18）治疗。治疗前后对心理病理症状进行评分，测试运动表现，并研究听觉和视觉感觉运动表现。在心理病理症状未改善的患者中，尤其是接受吗氯贝胺治疗的患者，出现了精神运动表现恶化的情况。这些发现提示，治疗药物可能与错误的递质系统相互作用，这可能是精神运动功能恶化的原因。
