Gifford Anne E, Farkas Kathleen J, Jackson Leila W, Molteno Christopher D, Jacobson Joseph L, Jacobson Sandra W, Bearer Cynthia F
International Society for Disease Surveillance, Boston, Massachusetts, USA.
Birth Defects Res A Clin Mol Teratol. 2010 Oct;88(10):838-46. doi: 10.1002/bdra.20731.
The objective of this report is to estimate the benefits of universal meconium screening for maternal drinking during pregnancy. Fetal alcohol spectrum disorder (FASD), including its most severe manifestation fetal alcohol syndrome (FAS), is preventable and remains a public health tragedy. The incidences of FAS and FASD have been conservatively estimated to be 0.97 and 10 per 1000 births, respectively. Meconium testing has been demonstrated to be a promising at-birth method for detection of drinking during pregnancy.
The current costs of FAS and FASD, alcohol treatment programs, and meconium screening were estimated by literature review. Monetary values were converted roughly to equal dollars in 2006.
Costs of adding meconium analysis to the current newborn screening program and of treatment for the identified mothers were estimated and compared to potential averted costs that may result from identification and intervention for mothers and affected infants. Three potential maternal treatment strategies are analyzed. Depending on the treatment type, the savings may range from $6 to $97 for every $1 spent on screening and treatment.
It needs to be emphasized, however, that such screening is premature and that to be effective this screening can be implemented only if there is a societal willingness to institute prevention and intervention programs to improve both women's and children's health. Future research should be directed at improving detection and developing in-depth prevention and remedial intervention programs. A thorough consideration of the ethical issues involved in such a screening program is also needed.
本报告的目的是评估对孕期母亲饮酒进行普遍胎粪筛查的益处。胎儿酒精谱系障碍(FASD),包括其最严重的表现形式胎儿酒精综合征(FAS),是可预防的,但仍是一场公共卫生悲剧。据保守估计,FAS和FASD的发病率分别为每1000例出生中有0.97例和10例。胎粪检测已被证明是一种很有前景的出生时检测孕期饮酒的方法。
通过文献综述估计了FAS和FASD、酒精治疗项目以及胎粪筛查的当前成本。货币价值大致换算为2006年的等值美元。
估计了在当前新生儿筛查项目中增加胎粪分析的成本以及对确诊母亲的治疗成本,并与因识别和干预母亲及受影响婴儿可能避免的潜在成本进行了比较。分析了三种潜在的母亲治疗策略。根据治疗类型的不同,每花费1美元用于筛查和治疗,节省的费用可能在6美元至97美元之间。
然而,需要强调的是,这种筛查为时过早,而且要想有效,只有在社会愿意制定预防和干预项目以改善妇女和儿童健康的情况下才能实施。未来的研究应致力于改进检测方法,并制定深入的预防和补救干预项目。还需要对这种筛查项目所涉及的伦理问题进行全面考虑。