Osswald W
Laboratório de Farmacologia, Faculdade de Medicina, Porto, Portugal.
J Neural Transm Suppl. 1990;32:395-404. doi: 10.1007/978-3-7091-9113-2_54.
Human vascular tissue (saphenous vein and uterine artery) was incubated with tritiated noradrenaline. In both vessels, oxidative deamination predominated over O-methylation. Deamination was due to the action of MAO type A and B, as well as of a semicarbazide-sensitive oxidase. Whereas DOPEG was a good index of intraneuronal deamination, NMN, DOMA and OMDA appeared to be entirely extraneuronal in origin. Extraneuronal deamination plays an important role in human vascular tissue and may contribute to the inactivation of circulating catecholamines.
将人体血管组织（大隐静脉和子宫动脉）与氚标记的去甲肾上腺素一起孵育。在这两种血管中，氧化脱氨作用比O-甲基化作用更为显著。脱氨是由A型和B型单胺氧化酶以及一种氨基脲敏感氧化酶的作用引起的。虽然二羟苯乙二醇是神经内脱氨的良好指标，但N-甲基去甲肾上腺素、3,4-二羟基-3-甲氧基扁桃酸和3-甲氧基-4-羟基扁桃酸似乎完全源自神经外。神经外脱氨在人体血管组织中起重要作用，可能有助于循环儿茶酚胺的失活。
