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通过同时测量血浆去甲肾上腺素和二羟基苯乙二醇（DOPEG）估算出的人体突触去甲肾上腺素浓度。

The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG).

作者信息

Ludwig J, Gerlich M, Halbrügge T, Graefe K H

机构信息

Medizinische Poliklinik, University of Würzburg, Federal Republic of Germany.

出版信息

J Neural Transm Suppl. 1990;32:441-5. doi: 10.1007/978-3-7091-9113-2_60.

DOI:10.1007/978-3-7091-9113-2_60
PMID:2089109
Abstract

A linear relationship between plasma DOPEG (ordinate) and plasma noradrenaline (NA; abscissa) was found during orthostasis as well as during NA infusion. The slope of the former (slopeR) was 13 times steeper than that of the latter (slopeI). This difference in slopes suggests that the NA concentration in the synaptic cleft is markedly higher than in plasma. The factor (F) characterizing this concentration difference was obtained from F2 = slopeR/slopeI. It amounted to 3.6.

摘要

在直立位以及去甲肾上腺素（NA）输注期间，发现血浆多巴胺-羟化酶（DOPEG，纵坐标）与血浆去甲肾上腺素（NA，横坐标）之间存在线性关系。前者的斜率（斜率R）比后者的斜率（斜率I）陡13倍。斜率的这种差异表明突触间隙中的NA浓度明显高于血浆中的浓度。表征这种浓度差异的因子（F）由F2 =斜率R/斜率I得出。其值为3.6。

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