Fukazawa T, Hamada T, Tashiro K, Moriwaka F, Yanagihara T
Hokuyukai Neurological Hospital, Sapporo, Japan.
J Neurol Sci. 1990 Dec;100(1-2):217-22. doi: 10.1016/0022-510x(90)90036-m.
Sixty-two consecutive patients with clinically definite multiple sclerosis (MS) were classified into 2 subgroups: group A, consisting of 16 patients who had shown acute transverse myelopathy (ATM) during the course of illness; and group B, 46 patients without ATM. The clinical features of these 2 groups were analysed prospectively for certain periods, and some significant differences were found. There was (1) later onset, (2) less frequent occurrence of brain stem, cerebellar and cerebral symptoms, (3) more frequent and severe involvement of the optic nerve, (4) a smaller proportion of patients with abnormal findings on brain MRI in group A compared with group B. The clinical features of group B were quite similar to those of previous Western series, while group A seemed to constitute a distinct clinical subgroup in patients with MS.
62例临床确诊的多发性硬化症（MS）患者被连续分为2个亚组：A组，由16例在病程中出现急性横贯性脊髓炎（ATM）的患者组成；B组，46例无ATM的患者。对这2组患者的临床特征进行了一定时期的前瞻性分析，发现了一些显著差异。存在（1）发病较晚，（2）脑干、小脑和脑部症状出现频率较低，（3）视神经受累更频繁且更严重，（4）与B组相比，A组脑MRI异常发现的患者比例较小。B组的临床特征与以往西方系列报道的非常相似，而A组似乎构成了MS患者中一个独特的临床亚组。
