Fukazawa T, Miyasaka K, Tashiro K, Hamada T, Moriwaka F, Yanagihara T, Hamada K
Hokuyukai Neurological Hospital, Sapporo, Japan.
J Neurol Sci. 1992 Jul;110(1-2):27-31. doi: 10.1016/0022-510x(92)90005-6.
We classified clinically definite multiple sclerosis (MS) patients who underwent brain MRI with superconductive magnet into 2 subgroups: group A, consisting of 14 patients who had shown acute transverse myelopathy (ATM) during the course of illness; and group B, 35 patients without ATM, and the same neuroradiologist, blinded to clinical profiles of the patients, investigated the MR scans. We analyzed some parameters such as distribution, size, shape and number of the lesions. Although the total number of lesions were similar in each group, and the number of small size or patchy shape solitary lesions were not different, the moderate, large, ovoid or confluent lesions were lower in number in group A, compared with group B. The degree of cerebral white matter lesions and periventricular lesions were higher in group B. Brainstem lesions were significantly less common in group A. These results show characteristic differences in MR-detected, possibly pathological, changes between these 2 groups, and support our previous report that group A may constitute a distinct subgroup in patients with MS.
我们将接受超导磁体脑部MRI检查的临床确诊多发性硬化症（MS）患者分为2个亚组：A组，由14例在病程中出现急性横贯性脊髓炎（ATM）的患者组成；B组，35例无ATM的患者。同一位对患者临床情况不知情的神经放射科医生对MRI扫描结果进行研究。我们分析了一些参数，如病灶的分布、大小、形状和数量。尽管每组病灶总数相似，且小尺寸或斑片状孤立病灶数量无差异，但与B组相比，A组中、大尺寸、椭圆形或融合性病灶数量较少。B组脑白质病灶和脑室周围病灶程度更高。A组脑干病灶明显较少见。这些结果显示了两组间MRI检测到的可能具有病理学意义的变化的特征性差异，支持了我们之前的报告，即A组可能构成MS患者中的一个独特亚组。
