Beatty J F, Krupin T, Nichols P F, Becker B
Arch Ophthalmol. 1984 Jul;102(7):1072-6. doi: 10.1001/archopht.1984.01040030866035.
Topical administration of three different calcium channel blockers (verapamil hydrochloride, diltiazem hydrochloride, or nifedipine) increased intraocular pressure transiently in rabbits. Outflow facility and episcleral venous pressure were unchanged. Aqueous humor flow seemed to be increased 30 minutes after topical application of verapamil when estimated by the Goldmann equation or by changes in anterior chamber fluorescein-labeled dextran concentration. However, aqueous humor ascorbate concentrations and turnover of radioactive iodide did not differ from that in the untreated eye. Ocular blood volume was found to be increased after topical application of verapamil, which suggested vascular changes as a possible mechanism for the induced increase in IOP. Topical verapamil raised IOP in healthy human volunteers, but the elevation was less than observed in rabbits. Single oral doses of verapamil in rabbits or human beings had no effect on IOP.
对兔子局部应用三种不同的钙通道阻滞剂（盐酸维拉帕米、盐酸地尔硫䓬或硝苯地平）会使眼压短暂升高。房水流畅度和巩膜静脉压未发生变化。当通过戈德曼方程或前房荧光素标记右旋糖酐浓度的变化进行估算时，局部应用维拉帕米30分钟后房水流量似乎有所增加。然而，房水抗坏血酸浓度和放射性碘的周转率与未治疗眼并无差异。局部应用维拉帕米后发现眼内血容量增加，这表明血管变化可能是眼压升高的一种机制。局部应用维拉帕米会使健康人类志愿者的眼压升高，但升高幅度小于在兔子中观察到的情况。兔子或人类单次口服维拉帕米对眼压没有影响。
